Enzymatic DNA Synthesis Technology

Nuclera is developing a next-generation DNA synthesis and automation platform based on engineered terminal deoxynucleotidyl transferases (TdT) to enable the production of gene and genome libraries. Our TdT enzymes are proven to quantitatively incorporate a wide variety of reversibly terminating nucleotide triphosphates of all four nucleobases. We are the only enzymatic DNA synthesis company capable of sequence-specific oligonucleotide production.

Patent portfolio:

  1. WO2016128731A1 
  2. WO2016139477A1
  3. WO2017009663A1
  4. GB2553274A