Technology

Making biology accessible

The eProtein desktop bioprinter delivers high value proteins through the novel combination of cell-free technologies and digital microfulidics.

eProtein™ Synthesis Ink

Nuclera’s eProtein synthesis bio-ink empowers scientists to perform protein discovery in 24hrs. Our bio-inks enable users to screen and print proteins through a diverse range of nature’s biofactories (organisms) and find the best expression system for their unique needs.

eProtein Synthesis

Screen a wide range of proteins

Our unique eProtein synthesis bioinks are whole cell extracts - cell free protein synthesis systems that benefit from the complex bio machinery present in cells without the need for specialised equipment. With Nuclera’s eProtein synthesis bioink you can screen for protein expression in mammalian, insect, plant, and bacterial cells at the same time and find your optimised expression system in a single day. 

Minimise your production time

Using eProtein synthesis bio-ink significantly reduces hands-on time. It enables the production of 'difficult' proteins such as transmembrane or toxic proteins and can increase yields of functional, soluble protein.

eDrop™ Digital Microfluidics

Our eDrop lab-on-a-chip technology employs cutting edge eProtein and eDNA synthesis bio-inks to make complex drug discovery workflows accessible on the benchtop.

Making biology accessible through digital microfluidics

Nuclera’s eDrop is a programmable lab-on-a-chip technology. Any bio workflow can be coded and faithfully translated to the nanoliter scale on the same Nuclera cartridge. Through truly integrated workflows, Nuclera can support life scientists throughout the experimental cycle, from design and biomolecule manufacture to data acquisition and analytics.

How does it work?

Our eDrop platform is based on TFT electronics, as used in the consumer electronics display industry.  Powered by the electrowetting effect, software controlled electronic signals change the interaction between a droplet and the surface to enable operations such as movement, mixing, and splitting. The high resolution of our eDrop platform (hundreds of thousands of electrodes) provides exquisite control of droplet operations, enables high parallelisation, and allows low volume (tens to hundreds of nanoliter) droplets to be created.

eDNA™ Synthesis Ink

Nuclera eDNA synthesis ink empowers scientists to convert their designs to DNA on the benchtop in a single day. As a foundational material for the life sciences, DNA is the springboard for many workflows. Our eDNA  synthesis ink allows your workflow to start without delay.

eDNA Synthesis

How does it work?

Our eDNA synthesis ink is powered by millions of years of evolution and several years of engineering in Nuclera laboratories. Nature and Nuclera combined have developed a polymerase capable of highly efficient enzymatic DNA synthesis. This engineered polymerase is fed by monomer building blocks (reversibly terminated nucleotides) also present in our eDNA synthesis ink. Using the power of programmable eDrop technology, the monomer building blocks are converted into DNA polymer of your desired sequence, right on your benchtop.

How will it revolutionise biology?

The power of eDNA synthesis ink is to connect workflows in the life sciences that are currently fragmented. Whenever protein is required, DNA is needed first. No DNA, no protein, no screen. True integration means seamless progression through the central dogma of biology - DNA, RNA, protein. Nuclera eDNA synthesis ink lets you write the DNA you need to start this process as soon as your design is ready.

Want to get access to the eProtein desktop bioprinter?

Our mission is simple: provide high-quality, soluble and active proteins at your benchtop.

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