Video – Accelerating Protein Engineering with AlphaFold integrated into eProtein Discovery™

This video showcases the seamless integration of AlphaFold into Nuclera’s eProtein Discovery™ Cloud software, enabling a powerful, structure-guided approach to protein engineering.

 

Researchers can now go from sequence to purified, soluble protein in just 48 hours by combining AI-driven 3D structure prediction with automated screening. The intuitive interface allows users to visualize protein structures, analyze critical features like domain annotations, hydrophobicity, and residue-level confidence, and strategically design protein variants that balance function with manufacturability.

 

Key capabilities featured in this demonstration include:

  • Interactive 3D modeling of predicted protein structures with zoom, rotate, and residue-level insights.
  • Dynamic visualization modes to assess structural confidence, functional domains, and hydrophobic regions.
  • Integrated protein variant editor to facilitate rational design and truncation/mutation decisions.
  • Bioinformatic validation tools such as multiple sequence alignment, pLDDT, and PAE plots to guide expression optimization.

 

Through AlphaFold integration, protein design becomes a data-informed, high-efficiency workflow — empowering researchers to solve protein folding and solubility challenges with unprecedented speed and precision.

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