This video showcases the seamless integration of AlphaFold into Nuclera’s eProtein Discovery™ Cloud software, enabling a powerful, structure-guided approach to protein engineering.
Researchers can now go from sequence to purified, soluble protein in just 48 hours by combining AI-driven 3D structure prediction with automated screening. The intuitive interface allows users to visualize protein structures, analyze critical features like domain annotations, hydrophobicity, and residue-level confidence, and strategically design protein variants that balance function with manufacturability.
Key capabilities featured in this demonstration include:
- Interactive 3D modeling of predicted protein structures with zoom, rotate, and residue-level insights.
- Dynamic visualization modes to assess structural confidence, functional domains, and hydrophobic regions.
- Integrated protein variant editor to facilitate rational design and truncation/mutation decisions.
- Bioinformatic validation tools such as multiple sequence alignment, pLDDT, and PAE plots to guide expression optimization.
Through AlphaFold integration, protein design becomes a data-informed, high-efficiency workflow — empowering researchers to solve protein folding and solubility challenges with unprecedented speed and precision.