The instrument bringing simplicity and automation to multiplex protein screening
Multiplex protein screening provides clarity on your protein from the start. The eProtein DiscoveryTM instrument streamlines protein project workflows with automated digital microfluidics to determine your direct path to soluble, purifiable proteins.
Features and benefits
Start here—on the instrument built for multiplex protein screening. Test more at the beginning without adding weeks of trial and error. The eProtein Discovery instrument miniaturizes and automates cell-free screens, ranks constructs, tags, custom cell-free conditions, and purification efficiency, and reports decision-grade readouts via on-cartridge fluorescence that quantifies only full-length, stable protein. Identify what works in 24 hours and scale to µg–mg of assay-ready protein on the benchtop overnight.
Designed for all levels of scientists, eProtein Discovery streamlines your protein workflows so you can pursue targets with confidence. Fail fast, succeed faster!
Set up with confidence
User-friendly interface with touchscreen-guided setup on a compact benchtop system. Start your 24 hour screen in minutes.
AI-powered digital automation
Automated nanoliter droplet control with AI tracking delivers up to 192 reliable, reproducible expression datapoints.
Built-in protein purification & quantification
Automated bead handling purifies proteins, while high-res optics and AI imaging detect aggregation and quantify only soluble, folded protein.
>1000 proteins generated with eProtein Discovery
Human soluble proteins synthesized with eProtein Discovery
Protein Class
Protein Name
- ScFv
- VHH
Membrane proteins synthesized with eProtein Discovery
Protein Class
Technical specifications
| Imaging system | A 20MP CMOS camera with specialized lighting system |
| Bead handling | Automated bead handling zones enables on-cartridge protein purification |
| Thermal control | 15-50 °C Cartridge Thermal Control |
| Display | 12.1 in 1024 px x 728 px touchscreen |
| Automation/motion control | Automated 80 nL precision droplet control |
| Instrument dimensions (in) | 14.5" (W) x 19.9" (D) x 17" (H) |
| Instrument dimensions (cm) | 40 cm (W) x 50.5 cm (D) x 43.5 cm (H) |
| Temperature and humidity | 59-86°F, 15-30°C (<80% non condensing humidity) |
| Weight | ≈ 40 pounds (18 kg) |
| Input power | 100-240 V, 50/60 Hz |
| Noise output | ≤ 52 dB(A) in operating mode (less than conversation) |
Featured Resource
On-demand Webinar: Accelerating Transcription Factor Discovery with Cell-Free Systems
In this webinar, Dr. Manoj Saxena (Birkbeck, University of London) presents a cell-free, microfluidic multiplex screening workflow that rapidly optimizes soluble transcription factor production. Using this approach, a novel target, Transcription Factor L (TF L) with LIM domains, a homeodomain, and extensive disorder, was produced alongside domain constructs and functionally validated by DNA-binding assays within 48 hours. This workflow moves researchers from disorder to data, enabling assay-ready proteins and accelerating discovery in developmental biology, regenerative medicine, and therapeutic development.
On-demand Webinar: Mastering Membrane Proteins in days with mimetic screening
Join Cube Biotech and Nuclera to discover a rapid, scalable workflow for expressing and stabilizing complex membrane proteins. Learn how Cube Biotech’s membrane mimetics combined with Nuclera’s eProtein Discovery system enable stable, functional, assay-ready membrane proteins in just 48 hours. This webinar highlights case studies on key drug targets, demonstrating how optimized membrane protein production…
